Arteriolar remodeling in essential hypertension: Are connective tissue growth factor and transforming growth factor involved?

Abstract

Gómez-Garre et al. report increased expression of connective tissue growth factor and transforming growth factor-β and worsening of remodeling in subcutaneous arterioles of patients with essential hypertension during amlodipine treatment. Losartan improves remodeling without changes in cytokine expression. The discordant effects of two well-accepted treatments for hypertension underline the need for further studies on therapy-induced changes in arteriolar remodeling. © 2006 International Society of Nephrology.