Spontaneous alternation and scopolamine

Abstract

Rats were tested for spontaneous alternation following injections of saline, scopolamine, and atropine, using doses of 0.4 and 1.2 mg/kg. It was found that scopolamine, at the higher dose, resulted in a reduction of alternation to a rate very near chance. A possible relation between the effects of scopolamine injection and removal of the hippocampus was discussed.