C-59 * A Portable Non-Invasive Multi-Modal Approach to Actively Assess Sports Concussion and Mild Traumatic Brain Injury

Abstract

Objective: To determine the degree to which skiing-related concussion can be identified from predictive models of neuropsychological testing data or in combination with single-lead electroencephalographic (EEG) data. Method: Adults who suffered traumatic brain injury (TBI; n = 26) while skiing were compared to n = 45 non-injured age matched comparator subjects in a cross-sectional study design under Aspire-IRB supervision. Each participant was tested using a novel single-lead EEG device during an eyes closed (EC) and eyes closed (EO) state. Further testing was performed during a neuropsychological saccade card test. Cognitive metrics (e.g., error-free card recital time) and EEG spectral and wavelet features were extracted from EC/EO baseline and neuropsychological test epochs. Univariate and multivariate logistic regression, linear discriminant analysis and random forest models were compared for the ability to predict a concussive event. Results: Independently, EEG spectral power in the beta band (12–30Hz), relative to overall power, had an overall predictive accuracy of 65% (p < 0.004). Additionally, total card read time alone was 62% accurate (p < 0.015). Combined, these two features were found to be 70% accurate (p < 0.006). However, including age and gender as co-variates with card read time and relative-beta EEG power were 76% accurate at differentiating concussed from control subjects (p < 0.003). Conclusion(s): Neuropsychological testing benefits by the addition of other testing modalities in the predictive performance of concussion/TBI testing. These results are preliminary and need to be independently replicated for validation and expanded to other clinical settings such as team sports and emergency department use. [ABSTRACT FROM AUTHOR] Copyright of Archives of Clinical Neuropsychology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)