Is there a role for estrogen in treating depression during menopause?

Abstract

Examine the effectiveness of estrogen as a treatment option in the management of depression in perimenopausal women. Five brief case illustrations are presented. Clinical data support the use of estrogen as a monotherapy or adjunctive strategy to antidepressants for vasomotor, sexual and other menopause-related symptoms. The authors recommend screening and management of risk factors for stroke considering estrogen therapy, and the use of transdermal E2 is particularly advisable owing to more efficacy data for mood improvement and a more promising cardiovascular profile owing to its effects on triglycerides and C-reactive protein levels and reduced risk for venous thromboembolism. (PsycINFO Database Record (c) 2012 APA, all rights reserved)