Core Aspects of Clinical Development and Trials in Chronic Idiopathic Constipation

Abstract

861 Huang SM and Woodcock J. (2009). Transporters in drug development:advancing on the Critical Path. Nat Rev Drug Discov. 2010 Mar;9(3):175-6 Irving G., Penzes J., Ramjattan B., et al (2011). A randomized, placebo-controlled phase 3 trial (study SB-767905/013) of alvimopan for opioid-induced bowel dysfunction in patients with non-cancer pain. J Pain. 12:175-84 Jansen J.P., Lorch D., Langan J., et al (2011). A randomized, placebo-controlled phase 3 trial (Study SB-767905/012) of alvimopan for opioid-induced bowel dysfunction in patients with non-cancer pain. J Pain. 12:185-93 Johanson J.F., Wald A., Tougas G. et al. (2004). Effect of tegaserod in chronic constipation: a randomized, double-blind, controlled trial. Clin Gastroenterol Hepatol 2: 796–805