Micellization behavior of amphiphilic drug promazine hydrochloride and sodium dodecyl sulfate mixtures at various temperatures: Effect of electrolyte and urea

Abstract

The aim of the current study is the characterization of interaction of amphiphilic drug promazine hydrochloride (PMZ) with sodium dodecyl sulfate (SDS) in the absence and presence of inorganic salt and urea. Conductometric measurements were carried out to estimate the critical micelle concentrations (CMC) of drug and surfactant along with their mixtures. A gradual reduce in the surface charge of the micelles was recognized due to the adding of salt pursued by a speedy enlargement of the micelles hence the CMC value of amphiphiles decreases. In the presence of urea an increase in the surface charge of the micelles was obtained ensuing halt of the micelle formation. Different parameters like ideal critical micelle concentration (CMCid), degree of dissociation (g), thermodynamic parameters, micellar mole fraction of SDS, and interaction parameter have been evaluated using relevant formula given in the literature. All results pointed out attractive interactions in the mixtures of drug and surfactant and showed effective involvement of the surfactant (SDS) component in the mixture. The combined effect of non-covalent is accountable for the micellization phenomena. Excess free energy of micellization (ΔGex) values was also evaluated and discussed in detail.