Effect of mianserin hydrochloride on peripheral uptake mechanisms for noradrenaline and 5‐hydroxytryptamine in man.

Abstract

1. Mianserin seems to have little effect on peripheral noradrenaline (NA) re‐uptake mechanisms as shown by its lack of effects on the tyramine dose and NA dose/pressor response. 2. Mianserin has no effect on the hypotensive action of bethanidine. 3. Mianserin in vivo has a significant action on platlet transport (Vmax) of 5‐hydroxytryptamine (5‐HT), which changes toward normal values in depressive patients on the drug. This action is not observed in vitro. 4. It is possible that a metabolite of mianserin is responsible for this effect, and that this may be of therapeutic importance. 1978 The British Pharmacological Society