Indoleamine 2,3 dioxygenase (IDO) expression and activity in relapsing-remitting multiple sclerosis

32Citations
Citations of this article
51Readers
Mendeley users who have this article in their library.

Abstract

Interferon gamma (IFN-γ) production induces the transcription of indoleamine 2,3 dioxygenase (IDO) resulting in the reduction of T-cell activation and proliferation through the depletion of tryptophan and the elicitation of Treg lymphocytes. IDO was shown to be involved in the pathogenesis of autoimmune diseases; we investigated whether changes in IDO gene expression and activity could be indicative of onset of relapse inmultiple sclerosis (MS) patients.

Cite

CITATION STYLE

APA

Mancuso, R., Hernis, A., Agostini, S., Rovaris, M., Caputo, D., Fuchs, D., & Clerici, M. (2015). Indoleamine 2,3 dioxygenase (IDO) expression and activity in relapsing-remitting multiple sclerosis. PLoS ONE, 10(6). https://doi.org/10.1371/journal.pone.0130715

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free