Abstract
RNA polymerase II (Pol II) transcription through chromatin is accompanied by formation of small intranucleosomal DNA loops. Pol II captured within a small loop drives accumulation of DNA supercoiling, facilitating further transcription. DNA breaks relieve supercoiling and induce Pol II arrest, allowing detection of DNA damage hidden in chromatin structure.
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Gerasimova, N. S., Pestov, N. A., Kulaeva, O. I., Clark, D. J., & Studitsky, V. M. (2016). Transcription-induced DNA supercoiling: New roles of intranucleosomal DNA loops in DNA repair and transcription. Transcription, 7(3), 91–95. https://doi.org/10.1080/21541264.2016.1182240
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