AN ECO-FRIENDLY PREPARATION OF 2,6-DIARYLPIPERIDIN-4-ONES USING A GLUCOSE-CHOLINE CHLORIDE DEEP EUTECTIC SOLVENT

Abstract

Deep Eutectic Solvent (DES) made with Glucose & Choline Chloride is an environmentally safe and sustainable technique for 2,6-diaryl piperidine-4-ones preparation. Starting with benzaldehyde, 2 or 4-hydroxybenzaldehyde, the preparation was carried out in ammonia using different ketones such as 2-pentanone, 3-pentanone, 2-propanone, 2-butanone. Under an atom-efficient method, all of the derivatives (a–f) were synthesized in good to outstanding yields. FT-IR,1HNMR,13CNMR, and GC-MS spectral methods were used to characterize the synthesized compounds. Choline chloride-glucose DES as a solvent has benefits over volatile organic solvents commonly utilized in similar processes.