Bone morphogenic protein signaling in spinal cord injury

  • Al-Sammarraie N
  • Ray S
N/ACitations
Citations of this article
8Readers
Mendeley users who have this article in their library.

Abstract

How to cite this article: Al-Sammarraie N, Ray SK. Bone morphogenic protein signaling in spinal cord injury. Neuroimmunol Neuroinflammation 2021;8:53-63. http://dx. Abstract Spinal cord injury (SCI) is a debilitating injury that results from traumatic or non-traumatic insults to the spinal cord, causing significant impairment of the patient's activity and quality of life. Bone morphogenic proteins (BMPs) are a group of polyfunctional cytokines belonging to the transforming growth factor beta superfamily that regulates a wide variety of cellular functions in healthy and disease states. Recent studies suggest that dysregulation of BMP signaling is involved in neuronal demyelination and death after traumatic SCI. The focus of this article is to describe our current understanding of the role of BMP signaling in the regulation of cell fate, proliferation, apoptosis, autophagy, and inflammation in traumatic SCI. First, we will describe the expression of BMPs and pattern of BMP signaling before and after traumatic SCI in rodent models and in vitro. Next, we will discuss the role of BMP in the regulation of neuronal and glial cell differentiation, survival, functional recovery from traumatic SCI, and the gap in knowledge in this area that requires further investigation to improve SCI prognosis.

Cite

CITATION STYLE

APA

Al-Sammarraie, N., & Ray, S. K. (2020). Bone morphogenic protein signaling in spinal cord injury. Neuroimmunology and Neuroinflammation, 2020. https://doi.org/10.20517/2347-8659.2020.34

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free