Role of aldose reductase in the metabolism and detoxification of carnosine-acrolein conjugates

Abstract

Background: Lipid peroxidation generates unsaturated aldehydes that form conjugates with histidyl dipeptides. Results: Carnosine-aldehyde conjugates form covalent adducts with proteins and are reduced by aldose reductase. Conclusion: Detoxification of carnosine-aldehyde by aldose reductase prevents protein carnosinylation. Significance: Aldose reductase prevents tissue injury due to aldehyde-carnosine conjugates. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.