Development and Evaluation of Buspirone Hydrochloride Loaded Transdermal Patch Using Natural Polymers

Abstract

The main objective of this present study was to design and develop a Buspirone hydrochloride matrix type transdermal drug delivery system (TDDS) with four natural gum polymers Guar gum, Gellan gum, Xanthan gum, Karaya gum. A total of twelve batches of matrix patches were formulated with the use of the abovestated polymers and other excipients like Glycerin, Propylene glycol (PG), and Polyethylene glycol (PEG) as plasticizers. These all batches were characterized by evaluation parameters which included drug content, flatness, thickness, uniformity of weight, folding endurance, moisture content, and moisture uptake to determine the amount of Buspirone hydrochloride present in the matrix of patches in vitro dissolution study of all twelve formulations were performed. FTIR and DSC were carried out to determine the interaction between Buspirone HCl and excipients that are present in the patch. Permeation study of a patch of Buspirone HCl was performed in Franz’s diffusion cell to evaluate In-vitro skin permeation and it was found that batch G3 shows 98.89% permeability. After evaluating all batches and based on results which are obtained from physical and chemical characterization and In-Vitro diffusion study it was concluded that patches containing natural polymers are not showing any interaction and better release study.