Anticancer activity of new 1,2,3-triazole-amino acid conjugates

Abstract

A multistep synthesis was developed to prepare new 1,2,3-triazole-amino acih conjugates (6 and 7). These compounds contain the hiaryl ether moiety and were synthesized via SNAr reaction under mild condition and in good yield. Their structures were confirmed by spectroscopic analyses (HR-MS, NMR, IR). These compounds showed significant antiproliferative activity (>30%) toward the breast MCF7 and liver HepG2 cancer cells lines at <10 uM concentration.