Non-enzymatic antioxidants and nutritional profiles in newly diagnosed pulmonary tuberculosis patients in nigeria.

Abstract

The effects of pulmonary tuberculosis on nutritional and antioxidants status was determined in thirty-one patients attending Chest Clinic, Oyo State Hospital, Jericho, Ibadan Nigeria by assessing the levels of total protein, albumin, globulin, total cholesterol, HDL cholesterol, LDL cholesterol, uric acid, vitamin C, vitamin E and total antioxidants. Thirty-four members of staff of State Hospital Adeoyo Ibadan, Nigeria were selected as controls. The mean levels of total protein (7.13+1.06g/dl), albumin (3.27+0.7g/dl), total cholesterol (100.7+23.6mg/dl), HDL cholesterol (28.6+7.2mg/dl), LDL cholesterol (65.5+15.1mg/dl) and triglycerides (61.6+16.2mg/dl) were significantly low while the level of globulin (3.9+0.84g/dl) was significantly high in pulmonary tuberculosis patients when compared with controls (total protein = 7.6+0.7g/dl; albumin = 4.2+0.48g/dl; total cholesterol = 163.2+40.1mg/dl; HDL cholesterol = 41.4+5.4mg/dl; LDL cholesterol = 107.8+27.5mg/dl; globulin= 3.4+0.6g/dl ). Levels of vitamin C (18.5+1.6mg/l), vitamin E (6.9+1.7mg/l) and total antioxidant (0.83+0.34mmol/l) were significantly lower while the level of uric acid (5.2+2.1mg/dl) was significantly higher in patients with pulmonary tuberculosis when compared with the controls (vitamin C = 23.1+2.3mg/l; vitamin E = 12.5+1.6mg/l; total antioxidant = 1.65+0.26mmol/l; uric acid = 4.3+1.2mg/dl respectively). Significantly lower levels of antioxidants might have been caused by endogenous uric acid production. (Afr. J. Biomed. Res. 10: 223 - 228)