Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway

Abstract

Background: IL-1β is a "master" proinflammatory cytokine central to host responses to injury and infection. Danger molecules (DAMPs) activate IL-1β via activation of a protease called caspase-1. Results: Acidosis promotes alternative DAMP-induced processing of IL-1β independent of caspase-1. Conclusion: Acidosis is a regulator of inflammatory pathways. Significance: Multiple pathways may contribute to the activation of IL-1 during disease. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.