One-step synthesis of magnetic hollow silica and their application for nanomedicine

Abstract

Magnetic nanoparticles are usually present in the form of magnetic carriers and used in nanomedicine and biosystem. In this paper, magnetic hollow silica (MHS) nanoparticles were fabricated by a one-step synthesis of Fe3 O4 nanoparticles and then coating of silica on nanosized spherical calcium carbonate under alkaline conditions, in which nanosized calcium carbonate (CaC O3, 25-60 nm) was used as a scarified template, tetraethoxysilane as a precursor, and Fe3 O4 nanoparticles (∼5 nm), formed in the initial reaction stage, as magnetic agents. The as-synthesized nanoparticles were immersed in a weak acetic acidic solution to remove CaC O3, forming MHS carriers. The nanostructures of the MHS carriers were characterized by scanning electron microscope, transmission electron microscope, and x-ray diffraction. Superconducting quantum interference device measurement exhibited that the MHS nanoparticles were superparamagnetic. Toxicity was tested for MHS carriers using rat brain microvascular endothelial cells. The cells treated with concentration lower than 50 μgml of the MHS nanoparticles showed no significant toxicity. After modification by silane coupling agent, the MHS carriers have strong absorption for ibuprofen in nanomedicine field. © 2006 American Institute of Physics.