Amelioration of streptozotocin-induced neurotoxicity in rats by a standardized extract of Cydonia oblonga seeds

Abstract

Background: Globally, medicinal plants are widely used to treat ailments due to their safety, accessibility and efficacy. Objectives: The objective of this study was to determine in vivo neuroprotective effect of methanolic extract of seeds of Cydonia oblongaagainst streptozotocin-induced diabetes in rats, as this research has not been reported previously. Methods: Methanolic extract (100, 150 and 200 mg/kg b.w) was administered for 21 days to diabetic rats. Total protein content, glutathione-S-transferase (GST) specific activity, total glutathione level (tGSH), catalase activity (CAT), malondialdehyde (MDA) level, superoxide dismutase (SOD) level and acetylcholinesterase (AChE) activity were determined in the brain homogenate. Results: C. oblonga seeds extract showed a significantly (*p < 0.05) increased in GST activity, tGSH level, CAT activity and level of SOD. While MDA levels and AChE activity were decreased in comparison with streptozotocin-treated group. Histopathological examination also showed a marked improvement in the morphology of brain tissues. Conclusion: It is concluded that the methanolic extract of C. oblonga seeds has the potential to protect the brain against streptozotocin-induced neurotoxicity by reducing oxidative stress and is beneficial for cognitive improvement in diabetic patients.