The particle design of cellulose and the other excipients for a directly compressible filler-binder

Abstract

Cellulose and saccharide are commonly used filler-binder. This summary refer to the technology for high performance filler-binder of direct compression, using these two materials. In case of saccharide filler-binder, spray dry technology and size controlling of primary particle were the key technology. In case of cellulose filler-binder, two different approaches were made. One was co-processing approach and the other was particle shape controlling approach. Some applications using high performance filler-binder were also introduced.