Serotype-specific differences in dengue virus non-structural protein 5 nuclear localization

Abstract

Background: Non-structural protein 5 (NS5) of dengue virus serotype 2 is predominantly localized in the nucleus. Results: The cellular localization of NS5 differs for the four dengue virus serotypes. Conclusion: NS5 nuclear localization is not a property shared by all dengue viruses. Significance: The identification of serotypic differences in the properties of dengue virus proteins is important for understanding viral pathogenesis and developing antiviral strategies. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.