Histochemical study of the skeletal muscle in children with chronic renal failure in dialysis treatment

Abstract

Among the modifications occurring in the uremic organism, in addition to the consequences of dialysis, myophathy and peripheral neuropathy are very significant. Children are particularly affected, as their growth and development are jeopardized. Histochemistry of muscular biopsy was used to study eighteen children with end-stage renal failure under dialysis during a ten-month period. According to our results, the skeletal muscular tissue presented the following types of alterations: atrophy, type grouping, lipidosis, glycogen depletion and mitochondrial proliferation.