Upon acute viral infection, virus-specific CD4+ T cells differentiate into either TH1 cells or follicular helper T (TFH) cells. The molecular pathways governing such bimodal cell fate commitment remain elusive. Additionally, effector virus-specific TFH cells further differentiate into corresponding memory population, which confer long-term protection against re-infection of same viruses by providing immediate help to virus-specific memory B cells. Currently, the molecular mechanisms underlying the long-term maintenance of memory TFH cells are largely unknown. In this review, we discuss current understanding of early differentiation of virus-specific effector TFH cells and long-term maintenance of virus-specific memory TFH cells in mouse models of viral infection and patients of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
CITATION STYLE
Wang, Y., Tian, Q., & Ye, L. (2022, July 14). The Differentiation and Maintenance of SARS-CoV-2-Specific Follicular Helper T Cells. Frontiers in Cellular and Infection Microbiology. Frontiers Media S.A. https://doi.org/10.3389/fcimb.2022.953022
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