Generation of Human Induced Pluripotent Stem (iPS) Cells from Liver Progenitor Cells by Two Chemicals and the Clinical Application

Abstract

only chemicals is not reported. On the other hand, loss of microRNA-145 elevates Oct3/4, Sox2 and Klf4 (1). Furthermore, TGF beta ligand elevates Sox2 (2). Therefore, when we can find human cells with endogenous expressions of Oct 3/4 and Sox2, even if their expressions were slight, it would be possible for us to generate the human iPS cells from the cells by using micro RNA-145 inhibitor and/or TGF beta ligand as chemicals appropriately.