Predictive value of osteoprotegerin and neutrophil gelatinase-associated lipocalin on multiple organ failure in multiple trauma

Abstract

Background/Aim: Multiple organ dysfunction syndrome (MODS) is the leading cause of late posttraumatic mortality. This study analyzed the prognostic values of osteoprotegerin (OPG) and neutrophil gelatinase-associated lipocalin (NGAL/lipocalin 2) compared to interleukin-6 (IL- 6) in multiply injured patients. Patients and Methods: A retrospective observational cohort study on multiply injured patients with an injury severity score (ISS) of .16 was performed. OPG, NGAL and IL-6 blood concentrations were measured. Statistical analysis comprised receiver-operatingcharacteristic (ROC) analysis with the corresponding area under the curve (AUC). Results: Thirty-nine patients with a mean ISS of 34±11 were included. Fourteen patients (36%) developed MODS and 8 patients (21%) died. Plasma levels of NGAL, OPG, and IL-6 were significantly elevated in the MODS+ group. Each biomarker positively correlated with MODS score and diagnosis of MODS. Conclusion: NGAL and OPG might be indicative of MODS and could have the potential to be biomarkers in the early detection of patients at risk of posttraumatic MODS.