Study on Association Between GSTP1 (rs1695) and Late-Onset Alzheimer Disease and Interaction With APOe4

Abstract

Objectives GSTs are detoxification enzymes that remove excess reactive oxygen species (ROS) from cells.\rEvidence suggests that oxidative stress plays a role in several stages of the neurodegenarative disease\rlike Alzheimer disease. Free radicals and similar molecules are classified as reactive oxygen species (ROS),\rwhich can cause oxidative modifications in the cell. In this study we have investigated the association\rbetween GSTP1 (rs1695) and AD risk for genetic variant in Iranian population.\rMethods & Materials The patient group consisted of 280 cases for GSTP1 gene investigation, whose Alzheimer\rdisease had been approved by psychologists based on clinical test (DSM-IV). The control group\rincluded 168 healthy individuals, satisfying the condition of not having any psychological disorders. Individuals’\rgenotype have been determined by PCR-RFLP method. Statistical analysis was done by logistic\rregression using OpenEpi 2.3.1 and SPSS 16.\rResults Significant association was observed between heterozygote genotype (AG) rs1695 A/G of GSTP1\rgene and the risk of Alzheimer disease (P=0.005, OR=0.57[0.38-0.84]).This genotype acts as a protective\rfactor. This observed result was significant in within women group (P=0.02). Significant interaction was\ralso found between heterozygote genotype (AG) rs1695 A/G of GSTP1 gene (protective factor) and absent\rε4 allele in our study group (P=0.001).\rConclusion Based on our results, we suggest that heterozygote genotype (AG) rs1695 A/G of GSTP1 gene\rcan act as a protective factor for Alzheimer disease in Iranian population.