Effect of garlic extract (Allium sativum) administration of the total cholesterol level for white rats (Rattus novergicus) with hypercholesterol

Abstract

Hypercholesterolemia is one of the non-contagious diseases which is the main cause of death globally. Accumulation of excessive cholesterol or hypercholesterolemia will be atherosclerosis which causes strokes and cardiovascular diseases such as coronary heart disease. Garlic has an active agent allicin which an alkaloid compound that was contained in garlic, can be used to reduce cholesterol levels, in addition: vitamin C and niacin. Knowing that effect of garlic extract (Allium sativum) to decrease cholesterol total levels in white rats (Rattus norvegicus) which are deliberately hypercholesterol.Experimental research through Pre test-post test with control group design approaching in laboratory. Research sample was 25 white rats selected randomly and divided into 5 groups are normal control group and treatment group. Data analysis by One Way ANOVA showed that total cholesterol levels on the 32, 33, 37 and 42 days was significance value of p <0.05, its means the statistical test showed that given the garlic extract (Allium sativum) can reduce total cholesterol levels in white rats with hypercholesterolemia. There is the effect of garlic extract (Allium sativum) on decreasing cholesterol total levels in white rats (Rattus novergicus) with hypercholesterol and a significant value (p <0.05).