Symmetry-Guided Design and Fluorous Synthesis of a Stable and Rapidly Excreted Imaging Tracer for19F MRI

Abstract

Getting FIT: A bispherical 19F imaging tracer, 19FIT, was designed and synthesized. 19FIT is advantageous over perfluorocarbon-based 19F imaging agents, as it is not retained in the organs and does not require complex formulation procedures. Imaging agents such as 19FIT can lead to 19F magnetic resonance imaging (MRI) playing an important role in drug therapy, analogous to the role played by 1H MRI in disease diagnosis. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.