Studies on antiulcer agents. I. The effects of various methanol and aqueous extracts of crude drugs on antiulcer activity

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Abstract

The antiulcer activities of 59 methanol and aqueous extracts obtained from 59 crude drugs on the ethanol-HCl-induced ulceration in rats were investigated. Among them 15 extracts were selected and they were further examined for their effects on indomethacin-, aspirin- and the water-immersion stress-induced ulcer. From these results, the methanol extract of root of Iris germanica was found to show potent antiulcer activities. The above methanol extract was separated into 3 portions by solvent extration, and the ether soluble portion was fractionated into 5 fractions (1 to 5) by chromatography. Fractions 4 and 5 showed significant antiulcer activities. Fraction 4 was further purified and the obtained γ-irigermanal exhibited a potent antiulcer activity. However, further investigations are required to understand the mechanism.

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Muto, Y., Ichikawa, H., Kitagawa, O., Kumagai, K., Watanabe, M., Ogawa, E., … Komatsu, M. (1994). Studies on antiulcer agents. I. The effects of various methanol and aqueous extracts of crude drugs on antiulcer activity. Yakugaku Zasshi, 114(12), 980–994. https://doi.org/10.1248/yakushi1947.114.12_980

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