THE USE OF THE GUINEA‐PIG ILEUM PREPARATION FOR TESTING THE ACTIVITY OF SUBSTANCES WHICH IMITATE OR ANTAGONIZE THE ACTIONS OF 5‐HYDROXYTRYPTAMINE AND TRYPTAMINE

Abstract

On the guinea‐pig ileum, 5‐hydroxytryptamine appeared to act in the same way as tryptamine on two types of receptor (morphine‐sensitive and phenoxybenzamine(Dibenzyline)‐sensitive). The actions of analogues of 5‐hydroxytryptamine on the phenoxybenzamine‐sensitive receptors resembled their actions on the rat uterus, and the actions on the morphine‐sensitive receptors slightly resembled those on the rat fundus strip. The guinea‐pig ileum preparation, however, did not appear to be more suitable than the rat uterus and rat fundus strip for testing the ability of compounds to imitate or antagonize 5‐hydroxytryptamine. 1959 British Pharmacological Society