Estudo de liberação e permeação in vitro do diclofenaco de dietilamônio em microemulsão gel-like

Abstract

IN VITRO RELEASE AND PERMEATION OF A DICLOFENAC DIETHYLAMINE FROM MICROEMULSION GEL-LIKE. The goal of this study was to produce and characterize a new microemulsion gel-like carrier system (MEG) by using the pseudo- ternary phase-diagram concept. The diclofenac diethylamine (DDA) was incorporated in the MEG and its in vitro release and permeation profiles were performed using Franz-type diffusion cells. The results revealed that the commercial DDA emulgel provided significantly higher Kp of DDA (2.2-fold) as compared to the MEG. Similar data were obtained in the permeation studies in which DDA Kp 4.7-fold higher. Therefore, MEG presents higher potential as a topical delivery system for DDA when compared to the commercial DDA emulgel.