Dopamine Receptor Modulation by Conformationally ConstrainedAnalogues of Pro-Leu-Gly-NH2

Abstract

Two series of conformationally constrained analogues of Pro-Leu-Gly-NH2 (PLG) have been synthesized. In one series of analogues, the Leu-Gly-NH2 dipeptide segment of PLG was replaced with the γ-lactam residues 3(S)-and 3(R)-amino-2-oxopyrrolidineacetamide and the γ-lactam residue 3(S)-amino-2-oxopiperidineacetamide. The corresponding γ-lactam analogues of