A unique carboxyl-Terminal insert domain in the hematopoietic-Specific, gtpase-Deficient rho gtpase rhoh regulates post-Translational processing

Abstract

RhoH is required for T cell development and non-coding RhoH mutations are found in B-cell lymphoma. Results: The C-terminal insert domain regulates RhoH protein stability via chaperone-mediated autophagy. Conclusion: Although the insert domain is required for lysosomal uptake, it is dispensable for T cell development. Significance: Targeting the insert domain may permit alteration of RhoH protein levels without impairing vital protein functions. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.