Enantio- and diastereoselective lntermolecular stetter reaction of glyoxamide and alkylidene ketoamides

Abstract

A triazolinylidene carbene catalyzed intermolecular Steuer reaction of glyoxamide and alkylidene ketoamides has been developed. 1,4-Dicarbonyl products are afforded In good to excellent yields, enantioselectivities, and diastereoselectivities. Further derivatization of the products affords useful Intermediates for organic synthesis. © 2009 American Chemical Society.