Here, we describe the alterations of neurotransmitters and neuropeptides that act on specific subreceptors in the<br />\r<br />brain areas involved in generalized epilepsy. A neurotransmitter imbalance between GABAergic and serotonergic<br />\r<br />neurons with hypoactivity and glutaminergic and dopaminergic neurons with hyperactivity is described. Considering<br />\r<br />the alterations in neurotransmitters and neuropeptides, neural networks in the hippocampus, hypothalamus,<br />\r<br />thalamus and cortex are described. The mechanisms of action of some recently developed antiepileptic drugs are<br />\r<br />addressed. In sum, a multimodal antiepileptic pharmacotherapy acting at several specific subreceptors is suggested.<br />\r<br />We recommend the development of an antiepileptic drug, that exerts simultaneously a GABAA agonistic and an<br />\r<br />NMDA antagonistic effect.
Rafael Covenas, F. M. W. (2015). Neuropeptides and Neurotransmitters Involved in Generalized Epilepsy: How Can the Antiepileptic Effect be Improved? Journal of Neurology & Neurophysiology, 06(04). https://doi.org/10.4172/2155-9562.1000303