Estriol review: Clinical applications and potential biomedical importance

Abstract

The clinical relevance and biological significance of estriol (E3), one of the three major human estrogens, are presented in this review. While initially having limited therapeutic indications, research has demonstrated E3’s utility as a biomarker to screen for disease, to test for placental function, and as a novel drug for human use. Current research is further exploring E3’s potential as a diagnostic and therapeutic tool.