Transition metal–catalyzed remote C-H borylation: An emerging synthetic tool

Abstract

Transition metal–catalyzed C-H bond activation and borylation is a powerful synthetic method that offers versatile synthetic transformation from organoboron compounds to virtually all other functional groups. Compared to the ortho-borylation, remote borylation remains more challenging owing to the inaccessibility of these C-H bonds. Enforcing the metal catalyst toward the remote C-H bonds needs well-judged catalyst design through proper ligand development. This review article aims to summarize the recent discoveries for the remote C-H borylation by the employment of new catalyst/ligand design with the help of steric of the ligand, noncovalent interactions. It has been found that C-H borylation now takes part in the total synthesis of natural products in a shorter route. Whereas, Ir-catalyzed C-H borylation is predominant, cobalt catalyst has also started to affect this field for sustainable and cost-effective development.