A Biomimetic Adhesive/Kaolin Material with Strong Adhesion, Sealing, and Active Coagulation Function for Arterial Hemostasis

Abstract

Effective prehospital hemostasis is pivotal for improving survival outcomes in arterial hemorrhage. Existing hemostatic materials have limitations in terms of both efficiency and portability, particularly under complex wound conditions. This study engineered a kaolin-reinforced biomimetic adhesive composite powder (DTG-K), which achieved dual hemostatic mechanisms: mechanical occlusion via strong interfacial adhesion (lap-shear strength of 58.3 kPa) and biochemical activation of the intrinsic coagulation pathway through factor XII. In vitro evaluations confirmed its exceptional hemocompatibility, with a 0.93% hemolysis rate. When applied to femoral artery hemorrhage models in Bama swine, DTG-K demonstrated complete hemostasis within 30 s through synergistic physical sealing and biochemical coagulation. These findings demonstrate the potential of DTG-K as an innovative strategy for managing life-threatening arterial hemorrhage in prehospital emergency scenarios.