Using mathematics to diagnose, cure, and predict cardiac arrhythmia

Abstract

Mathematics can be used to analyze and model cardiac arrhythmia. I discuss three different problems. (1) Diagnosis of atrial fibrillation based on the time intervals between subsequent beats. The probability density histograms of the differences of the intervals between consecutive beats have characteristic shapes for atrial fibrillation. (2) Curing atrial fibrillation by ablation of the core of rotors. Recent clinical studies have proposed that ablating the core of rotors in atrial tissue can cure atrial fibrillation. However, the claims are controversial. One problem that arises relates to difficulties associated with developing algorithms to identify the core of rotors. In model tissue culture systems, heterogeneity in the structure makes it difficult to unambiguously locate the core of rotors. (3) Risk stratification for sudden cardiac death (SCD). Despite numerous clinical studies, there is still a need for improved criteria to assess the risk of SCD. I discuss the possibility of using the dynamics of premature ventricular complexes to help make predictions. The development of wearable devices to record and analyze cardiac rhythms offers new prospects for the diagnosis and treatment of cardiac arrhythmia.