Tailorable drug capacity of dexamethasone-loaded conducting polymer matrix

Abstract

The unique properties of conducting polymers, which are in the same time biocompatible and electrically responsive materials, make them perfect candidates for controlled drug release systems. In this study, the electrically-triggered controlled release system based on dexamethasone-loaded poly (3, 4-ethylenedioxypyrrole) (PEDOP) matrix is described. It is shown that the electropolymerization conditions can facilitate or suppress the formation of PEDOP/Dex matrix, as well as they can have the effect on its electrochemical performance. The release experiments performed in three different modes show that the drug capacity of PEDOP matrix increases with the increase in Dex concentration in the step of matrix synthesis, and higher Dex concentrations make it easier to control the amount of Dex released in an electrically-triggered mode. These results confirm the importance of the careful optimization of immobilization conditions to maximize drug capacity of matrix and maintain its electrochemical properties.