Effective adsorption of doxorubicin hydrochloride on the green targeted nanocomposite

Abstract

This study examined the adsorption properties of the doxorubicin anticancer drug on a designed and fabricated system. A novel nanocomposite based on green magnetic - Graphene Oxide - Chitosan - Allium Sativum - Quercus was successfully fabricated. To evaluate the doxorubicin adsorption, the effectiveness parameters on the adsorption process were investigated including the contact time, pH value, concentration, the adsorbent dosage, and temperature. The results indicated that the maximum adsorption of doxorubicin on the fabricated nanocomposite occurred at pH 6.3, concentration 3.6 mg/1.8 ml, contact time 10 minutes, and the adsorbent dosage 1.4 g/L. This designed system not only increased the drug adsorption up to 100%, but it also can absorb low concentrations of doxorubicin. This suggests that the current challenge in using the higher concentrations of doxorubicin could be essentially minimized thanks to the excellent components used in the nanocomposite structure. The developed system has greatly improved DOX adsorption, confirming that the fabricated nanocomposite could be applied for a drug delivery.