Renal clearance of mineral metabolism biomarkers

34Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.

Abstract

CKDleads to disturbances inmultiple interrelated hormones that regulate bone and mineralmetabolism. The renal handling of mineralmetabolism hormones in humans is incompletely understood. We determined the single-pass renal clearance of parathyroid hormone, fibroblast growth factor 23, Vitamin D metabolites, and phosphate frompaired blood samples collected fromthe abdominal aorta and renal vein in 17 participants undergoing simultaneous right and left heart catheterization and estimated associations of EGFR with the renal elimination of metabolites. The mean age 6SD of the study population was 71.4610.0 years and 11 participants (65%) were male.We found a relatively large mean6SD single-pass renal extraction of parathyroid hormone (44.2%610.3%) that exceeded the extraction of creatinine (22.1%67.9%). The proportionate renal extraction of parathyroid hormone correlatedwith EGFR. The renal extraction of fibroblast growth factor 23 was, on average, lower than that of parathyroid hormone with greater variability across individuals (17.1%619.5%). There were no differences in the mean concentrations of Vitamin D metabolites across the renal vein and artery. In summary, we demonstrate substantial single-pass renal extraction of parathyroid hormone at a rate that exceeds glomerular filtration. Impaired renal clearance of parathyroid hormone may contribute to secondary hyperparathyroidism in CKD.

Cite

CITATION STYLE

APA

Van Ballegooijen, A. J., Rhee, E. P., Elmariah, S., De Boer, I. H., & Kestenbaum, B. (2016). Renal clearance of mineral metabolism biomarkers. Journal of the American Society of Nephrology, 27(2), 392–397. https://doi.org/10.1681/ASN.2014121253

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free