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Comparative RNAi Screens in Isogenic Human Stem Cells Reveal SMARCA4 as a Differential Regulator

Stem Cell Reports (2019) 12(5) 1084-1098
DOI: 10.1016/j.stemcr.2019.03.012
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Abstract

Güneş et al. show that RNAi screens on genetically identical (isogenic)human stem cells can dissect epigenetic factors important for self-renewal versus differentiation. By using iPSCs as a bridging cell type, the comparative RNAi screens in HSPCs and NSCs identify SMARCA4 as an important regulator of self-renewal and differentiation with cell-type-specific functions.

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Güneş, C., Paszkowski-Rogacz, M., Rahmig, S., Khattak, S., Camgöz, A., Wermke, M., … Buchholz, F. (2019). Comparative RNAi Screens in Isogenic Human Stem Cells Reveal SMARCA4 as a Differential Regulator. Stem Cell Reports, 12(5), 1084–1098. https://doi.org/10.1016/j.stemcr.2019.03.012

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