An eco-efficient new path of mortar pestle grinding approach for the construction of methanol and ethylthio substituted pyridines with in silico studies

Abstract

A green and highly regioselective approach for the synthesis of poly-substituted new pyridine derivatives via the Knoevenagel condensation followed by the Michael addition. The reaction involves intramolecular cyclization of easily obtainable reactants under environmentally and economically benign mortar pestle grinding technique. This method clearly proves that spatially hindered aldehydes also actively contribute to the construction of the desired pyridine derivatives with good yield (85%–96%) in about 30–40 min. This new avenue offers a number of benefits over earlier reaction approaches such as lengthy work-up-processes, operational difficulties and lower yields. This mortar pestle grinding technique is familiar for environmental and economical benign protocols. The druggability properties of synthesized compounds assessed using in silico studies.