Coupling reaction of grignard reagents with α,ω-dibromo-alkanes in the presence of copper(I) bromide-HMPA: Preparation of α,ω-bis(vinylaryl)alkanes

Jun Nishimura; Noriyuki Yamada; Yuzuru Horiuchi; Eiji Ueda; Akihiro Ohbayashi; Akira Oku

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Coupling reaction of grignard reagents with α,ω-dibromo-alkanes in the presence of copper(I) bromide-HMPA: Preparation of α,ω-bis(vinylaryl)alkanes

Bulletin of the Chemical Society of Japan (1986) 59(6) 2035-2037

DOI: 10.1246/bcsj.59.2035

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Abstract

Synopsis. The coupling reaction of Grignard reagents with α,ω-dibromoalkanes took place smoothly in THF/ HMPA (12:1) in the presence of a catalytic amount of copper(I) bromide and gave the products in 60-100% yields. Several α,ω-bis(vinylaryl)alkanes were prepared in reasonable yields by the application of this reaction.

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Nishimura, J., Yamada, N., Horiuchi, Y., Ueda, E., Ohbayashi, A., & Oku, A. (1986). Coupling reaction of grignard reagents with α,ω-dibromo-alkanes in the presence of copper(I) bromide-HMPA: Preparation of α,ω-bis(vinylaryl)alkanes. Bulletin of the Chemical Society of Japan, 59(6), 2035–2037. https://doi.org/10.1246/bcsj.59.2035

Coupling reaction of grignard reagents with α,ω-dibromo-alkanes in the presence of copper(I) bromide-HMPA: Preparation of α,ω-bis(vinylaryl)alkanes

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