The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics

Abstract

Background:Precise spatiotemporal rearrangement of the actin cytoskeleton is essential for cell migration and adhesion. Results:SWAP-70 bundles actin filaments and interacts with cofilinin vitroand in murine mast cells. Conclusion:SWAP-70 is a parallel and anti-parallel bundling protein that participates in the organization of F-actin networks. Significance: Identification and characterization of a regulator of F-actin dynamics improve our understanding on the spatiotemporal control of cytoskeletal processes. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.