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The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis

Cell Reports (2020) 30(12) 4052-4064.e7
DOI: 10.1016/j.celrep.2020.02.098
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Abstract

Mesquita et al. show that genetic deficiency of HIF-1α in the myeloid compartment promotes de novo lipogenesis through the BNIP3/mTOR/SREBP-1c axis. This is associated with higher susceptibility to Leishmania donovani infection, which is reduced upon pharmacological inhibition of fatty acid synthesis.

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Mesquita, I., Ferreira, C., Moreira, D., Kluck, G. E. G., Barbosa, A. M., Torrado, E., … Silvestre, R. (2020). The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis. Cell Reports, 30(12), 4052-4064.e7. https://doi.org/10.1016/j.celrep.2020.02.098

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