Organocatalysis emerging as a technology

Abstract

During the last 20 years, organocatalysis has significantly advanced as a field. Thanks to contributions from hundreds of groups and companies around the world, the area has risen from a few mechanistically ill-defined niche reactions, to one of the most vibrant and innovative fields in chemistry, providing several well-defined generic activation modes for selective catalysis. Organocatalysis is also on the rise in industrial settings, especially for the production of enantiomers, which are of use in fine chemistry, pharma, crop-protection, and fragrance chemistry. Here we will look at some of the specific elements of organocatalysis that we think are particularly attractive and contribute to this successful development.