Construction of a Photoelectrochemical Sensor Based on FeTCP@ZnO for the detection of Oxytetracycline

Abstract

This paper proposes a photoactive nanomaterial of zinc oxide (ZnO) sensitized with iron (III) tetracarboxy phthalocyanine (FeTCPc), and develops a photoelectrochemical (PEC) method for the rapid and trace determination of oxytetracycline hydrochloride. In the preparation process, a simple one-step hydrothermal method is used to compound FeTCPc@ZnO/ITO, followed by fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) and x-ray diffraction (XRD) and other characterization methods to confirm the composition and morphology of ZnO and FeTCPc. Take various methods to study the photocurrent response of oxytetracycline on bare/ITO, FeTCPc@ZnO/ITO, FeTCPc/ITO, ZnO/ITO and CTS/ITO respectively, and optimize each detection condition, make it show the strongest response. Apparently, the photoelectric response for detection of hygromycin was most significant when FeTCPc was used in combination with ZnO. The results show that under optimal conditions, the photocurrent response intensity of the constructed PEC is inversely proportional to the concentration of oxytetracycline, and the logarithmic range of 0.5 nM ~ 0.25 mM has a good linear relationship and linear regression. In addition, the PEC has excellent reproducibility and stability. The proposed photoelectrochemical sensor was applied to the detection of actual drug oxytetracycline, and the result is close to the drug labeling amount, which is relatively satisfactory.