Role of G protein β3 subunit C825T and HLA class II polymorphisms in the immune response after HBV vaccination

36Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The G protein β3 (GNB3) subunit and HLA are candidate genes predictive of immune response capacity. We therefore studied the influence of both gene systems on cellular and humoral immunity against hepatitis B virus (HBV) in 79 HBV booster-vaccinated healthy volunteers and an independent group of 77 probands after HBV basic immunization. Following booster vaccination, lymphocyte in vitro proliferation after stimulation with HBV surface antigen was 2.5-fold increased in GNB3 825T (TC + TT) vs CC allele carriers (P = 0.01) and was not influenced by HLA-DRB1 or DQB1 alleles. In addition, anti-HBs antibody titers in both groups were 2-fold increased in TC vs CC and decreased in TT vs CC allele carriers. However, antibody titers after HBV booster immunization were elevated in HLA-DQB1*0301 carriers (P corrected = 0.027). In summary, the GNB3 825T allele appears as a marker particularly predictive of cellular and HLA-DQB1*0301 of humoral immune responses following HBV vaccination. © 2001 Elsevier Science Ltd. All rights reserved.

Cite

CITATION STYLE

APA

Lindemann, M., Barsegian, V., Siffert, W., Ferencik, S., Roggendorf, M., & Grosse-Wilde, H. (2002). Role of G protein β3 subunit C825T and HLA class II polymorphisms in the immune response after HBV vaccination. Virology, 297(2), 245–252. https://doi.org/10.1006/viro.2002.1467

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free