Postradiation multicentric osteosarcoma

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Abstract

The oncogenic effects of radiation are well‐established. Osteosarcomas and fibrosarcomas are the two most common histologic types of secondary sarcoma. In this article a case of postradiation osteosarcoma is presented in which four discrete foci of sarcomatous transformation have occurred in the tibia and fibula after irradiation for a rhabdomyosarcoma of the calf 8 years earlier. A review of the literature reveals no similar case. Although synchronous, multifocal osteosarcoma without prior radiation has been described, this case differs in clinical, radiographic, and pathologic features; it best fits the description of postradiation multicentric osteosarcoma. Copyright © 1988 American Cancer Society

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Tillotson, C., Rosenberg, A., Gebhardt, M., & Rosenthal, D. I. (1988). Postradiation multicentric osteosarcoma. Cancer, 62(1), 67–71. https://doi.org/10.1002/1097-0142(19880701)62:1<67::AID-CNCR2820620114>3.0.CO;2-Q

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